| Abstrakt: |
The biological and biochemical effects induced by transvaginal treatment with biologically active iodine have been examined with and without the reference severe irritant for chicken embryos and chicks, which are considered the most popular model systems for investigation of a drug's action in veterinary medicine. An increase in the thyroid activity in the experimental group chickens during the first days of their life is reveled and analyzed. Under the impact of the thermal stress factor, the levels of the iodothyronines were elevated. In particular, it was 1.3 times, 20.9%, 23.2%, and 1.3 times higher for total T3, free T3, total T4, and free T4, respectively, in the experimental chickens compared to the control. Under the reference optimization of the thyroid status, the antioxidant defense system in the organisms of the 1-day-old chickens in experimental group two was activated, resulting in the significant increase in the blood serum antioxidant activity, which was 1.3 higher than that in the control group of chickens. This caused a decrease in the levels of the lipids containing the isolated double bonds, the diene conjugates, the triene conjugates, the oxodiene conjugates, and the Schiff bases, whose levels decreased by 8.8%, 1.4 times, 16.3%, 1.5 times, and 1.4 times, respectively. The key aspects of the iodothyronine mechanism of action at the high intensity of the free radical reactions followed by lipid peroxidation are shown in the form of a diagram in Fig. 1. The results of the survey can offer the opportunity to use the drug products based on the chemical element indicated above properly by the veterinarians and health workers. The more that the stressors affect the organism of a bird, the greater is the antioxidant effect exerted by the thyroid hormones. [ABSTRACT FROM AUTHOR] |
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