Eluxadoline-induced pancreatitis occurring in an adult man without a prior cholecystectomy.

Autor: Shahid, Zainab, Packard, Elizabeth, Groff, Andrew, Jain, Rohit
Zdroj: BMJ Case Reports; 8/27/2019, Vol. 12 Issue 8, p1-3, 3p, 2 Black and White Photographs
Abstrakt: Eluxadoline is a novel medication that was approved in the USA in 2015 for the treatment of diarrhoeapredominant irritable bowel syndrome. Due to its unique mechanism of action as both an opioid agonist and antagonist, it has been placed as a schedule IV controlled substance. Since its approval, there have been several cases of eluxadoline-induced pancreatitis reported in the literature. The majority of patients who presented with eluxadoline-induced pancreatitis were reported to have had a prior cholecystectomy. Due to this, the Food and Drug Administration released a warning in 2017 that eluxadoline should no longer be used in patients who do not have a gall bladder. We present a rare case of an adult man without prior cholecystectomy who presented with severe midepigastric pain and was found to have eluxadolineinduced pancreatitis. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index