| Autor: |
Jaiswal, Manoj, Dubey, B. K., Pandey, Grijesh Kumar, Yadav, S. K., Parkhe, Geeta |
| Předmět: |
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| Zdroj: |
Journal of Drug Delivery & Therapeutics; 2019 Supplement, Vol. 9, p394-397, 4p |
| Abstrakt: |
The concept of fast dissolving dosage form has become popular as new delivery system. This system will provide maximum therapeutic efficacy, increased bioavailability and maximum stability by reducing the frequency of dosage. It will also avoid first pass metabolism of the drugs. This system provides more rapid drug absorption from the pre gastric area which may provide quick onset of action. Trazodone hydrochloride an serotonin reuptake inhibitor, antidepressant. Trazodone undergoes first pass metabolism on oral administration resulting in reduced bioavailability (60%). Thus the objective of the present study was to formulate and evaluate fast dissolving oral films of Trazodone to overcome the limitation of bioavailability and increase patient’s compliance. In the present study oral films were prepared by solvent casting method using HPMC K15 as a film formers and PEG 400 as plasticizers and evaluated for mechanical properties, disintegration and in vitro dissolution. All formulations showed good mechanical properties and in vitro drug release. The optimized (F3) formulation exhibited drug release of 92.12% in 5 minutes which was significantly high when compared to other formulation. It is evident from the above results that the developed formulation can be an innovative dosage form to improve the drug delivery, onset of action as well as improve patient compliance. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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