| Autor: |
McElheny, Kathryn, Toresdahl, Brett, Ling, Daphne, Mages, Keith, Asif, Irfan |
| Předmět: |
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| Zdroj: |
Sports Health: A Multidisciplinary Approach; Sep/Oct2019, Vol. 11 Issue 5, p461-466, 6p |
| Abstrakt: |
Context: Viscosupplementation is widely used for management of knee osteoarthritis. Many formulations of hyaluronic acid (HA) are available, ranging from a single injection to a series of up to 5 injections per treatment.Objective: To compare efficacy between single and multiple HA injection formulations.Data Sources: MEDLINE, EMBASE, Cochrane, Web of Science, Scopus databases were all searched.Study Selection: Full-text prospective randomized and nonrandomized controlled human trials, cohort studies, and cost-effectiveness evaluations in the English language comparing different injection regimens of viscosupplementation were included.Study Design: Systematic review.Level Of Evidence: Level 1.Data Extraction: Data were collected using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Four databases were searched by a librarian and the principal investigator, identifying 6196 articles for screening.Results: Eleven studies met the inclusion criteria. Of the studies comparing single- with multiple-injection formulations of HA for treatment of knee osteoarthritis, there was no consistent difference in patient-reported outcomes. Furthermore, 5-injection formulations do not appear to be superior to 3-injection formulations.Conclusion: There are limited head-to-head trials comparing viscosupplementation formulations that differ based on number of injections, and in particular, there is a paucity of trials evaluating single-injection formulations. Based on the currently available data, there appears to be similar efficacy with the possibility for greater cost-effectiveness and less patient inconvenience with single-injection formulations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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