Genotyping Approach for Potential Common Source of Enterocytozoon bieneusi Infection in Hematology Unit.

Autor: Desoubeaux, Guillaume, Nourrisson, Céline, Moniot, Maxime, De Kyvon, Marie-Alix, Bonnin, Virginie, De La Bretonniére, Marjan Ertault, Morange, Virginie, Bailly, Éric, Lemaignen, Adrien, Morio, Florent, Poirier, Philippe
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Zdroj: Emerging Infectious Diseases; Sep2019, Vol. 25 Issue 9, p1625-1631, 7p
Abstrakt: Microsporidiosis is a fungal infection that generally causes digestive disorders, especially in immunocompromised hosts. Over a 4-day period in January 2018, 3 patients with hematologic malignancies who were admitted to the hematology unit of a hospital in France received diagnoses of Enterocytozoon bieneusi microsporidiosis. This unusually high incidence was investigated by sequence analysis at the internal transcribed spacer rDNA locus and then by 3 microsatellites and 1 minisatellite for multilocus genotyping. The 3 isolates had many sequence similarities and belonged to a new genotype closely related to genotype C. In addition, multilocus genotyping showed high genetic distances with all the other strains collected from epidemiologically unrelated persons; none of these strains belonged to the new genotype. These data confirm the epidemiologic link among the 3 patients and support a common source of infection. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index