| Autor: |
Acquaviva, Massimo, Bassani, Claudia, Sarno, Nicole, Dalla Costa, Gloria, Romeo, Marzia, Sangalli, Francesca, Colombo, Bruno, Moiola, Lucia, Martinelli, Vittorio, Comi, Giancarlo, Farina, Cinthia |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology; 8/14/2019, p1-6, 6p |
| Abstrakt: |
Recent evidence suggests that the primary progressive form of multiple sclerosis (PP-MS) may present with specific immunological alterations. In this study we focused our attention on CD161, an NK and T cell marker upregulated in relapsing-remitting MS, and investigated its transcript and protein levels in blood cells from PP-MS and healthy individuals. We demonstrated transcriptional downregulation of CD161 in PP-MS and described concomitant mRNA reduction for RORgt, CCR6, CXCR6, KLRK1/NKG2D and many other markers typical of mucosa associated invariant T (MAIT) cells. Targeted multiparametric flow cytometry on fresh blood cells from an independent cohort of case-control subjects confirmed the selective loss of circulating CD8 CD161high T cells, which consist mainly of MAIT cells, and not of CD8 CD161int T cells in PP-MS. These data demonstrate alterations in a specific circulating immune cell subset in MS patients with progressive onset. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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