| Autor: |
Taniguchi, Chiho, Sugawara, Takehiro, Onoue, Sakura, Kawahara, Kazuyoshi |
| Předmět: |
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| Zdroj: |
Microbiology & Immunology; Aug2019, Vol. 63 Issue 8, p334-337, 4p |
| Abstrakt: |
Lipid A in lipopolysaccharide (LPS) of Escherichia coli mutant strains was modified by the introduction of myristoyltransferase gene cloned from Klebsiella pneumoniae. When the gene was introduced into the mutant having lipid A containing only 3‐hydroxymyristic acids, it produced lipid A with two additional myristic acids (C14:0). When the same gene was introduced into the mutant with pentaacylated lipid A containing one lauric acid (C12:0), C12:0 was replaced by C14:0. IL‐6‐inducing activity of LPS with modified lipid A structure suggested that C12:0 in lipid A could be replaced by C14:0 without changing the immunostimulating activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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