Azithromycin-based Extended-Spectrum Antibiotic Prophylaxis for Cesarean: Role of Placental Colonization with Genital Ureaplasmas and Mycoplasmas.
| Autor: | Subramaniam, Akila, Waites, Ken B., Jauk, Victoria C., Biggio, Joseph R., Sutton, Amelia L. M., Szychowski, Jeff M., Andrews, William W., Tita, Alan T. N. |
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| Předmět: |
AZITHROMYCIN
CEFAZOLIN SURGICAL site infections AMNION CESAREAN section CONFIDENCE intervals ENDOMETRIAL diseases GRAM-negative bacterial diseases HOST-bacteria relationships MEDICAL cooperation MYCOPLASMA diseases PLACENTA POLYMERASE chain reaction PUERPERIUM RESEARCH WOMEN'S health LOGISTIC regression analysis RANDOMIZED controlled trials TREATMENT effectiveness BLIND experiment ANTIBIOTIC prophylaxis ODDS ratio THERAPEUTICS PREVENTION |
| Zdroj: | American Journal of Perinatology; 2019, Vol. 36 Issue 10, p1002-1008, 7p |
| Abstrakt: | Objective To explore whether the effect of azithromycin (AZI) on postcesarean infections varied by the presence/absence of genital mycoplasmataceae placental colonization. Study Design This was a single-center substudy of multicenter double-blind C/SOAP (Cesarean Section Optimal Antibiotic Prophylaxis) trial of women randomized to AZI or placebo (+cefazolin) antibiotic prophylaxis at cesarean. Chorioamnion/placenta specimens were tested for genital mycoplasmataceae colonization by polymerase chain reaction. Primary outcome was a composite of endometritis, wound infection, or other infections up to 6 weeks postpartum. Analysis was intent-to-treat; logistic regression was used to evaluate interactions between treatment assignment (AZI/placebo) and the presence/absence of mycoplasmataceae and to quantify effects of AZI in analyses stratified by the presence/absence of these microorganisms. Results Specimens from 613 women (303 AZI and 310 placebo) were evaluated. Baseline characteristics were similar between groups, and approximately 1/3 (30.3%) had mycoplasmataceae placental/chorioamnion colonization. There was no evidence of effect modification (p |
| Databáze: | Complementary Index |
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