| Autor: |
Dan Hu, Notarbartolo, Samuele, Croonenborghs, Tom, Patel, Bonny, Cialic, Ron, Yang, Tun-Hsiang, Aschenbrenner, Dominik, Andersson, Karin M., Gattorno, Marco, Pham, Minh, Kivisakk, Pia, Pierre, Isabelle V., Lee, Youjin, Kiani, Karun, Bokarewa, Maria, Tjon, Emily, Pochet, Nathalie, Sallusto, Federica, Kuchroo, Vijay K., Weiner, Howard L. |
| Předmět: |
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| Zdroj: |
Nature Communications; 11/17/2017, Vol. 8 Issue 1, p1-14, 14p |
| Abstrakt: |
We have previously reported the molecular signature of murine pathogenic TH17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-β+IL-17+ (TH1/17) and IFN-β.IL-17+ (TH17) CD4+ T cells display distinct transcriptional profiles in high-throughput transcription analyses. Compared to TH17 cells, TH1/17 cells have gene signatures with marked similarity to mouse pathogenic TH17 cells. Assessing 15 representative signature genes in patients with multiple sclerosis, we find that TH1/17 cells have elevated expression of CXCR3 and reduced expression of IFNG, CCL3, CLL4, GZMB, and IL10 compared to healthy controls. Moreover, higher expression of IL10 in T H17 cells is found in clinically stable vs. active patients. Our results define the molecular signature of human pro-inflammatory TH17 cells, which can be used to both identify pathogenic TH17 cells and to measure the effect of treatment on TH17 cells in human autoimmune diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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