| Autor: |
Steff, Ann-Muriel, Monroe, James, Friedrich, Kristian, Chandramouli, Sumana, Thi Lien-Anh Nguyen, Sai Tian, Vandepaer, Sarah, Toussaint, Jean-François, Carfi, Andrea |
| Předmět: |
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| Zdroj: |
Nature Communications; 10/20/2017, Vol. 8 Issue 1, p1-10, 10p |
| Abstrakt: |
Human respiratory syncytial virus (hRSV) is responsible for serious lower respiratory tract disease in infants and in older adults, and remains an important vaccine need. RSV fusion (F) glycoprotein is a key target for neutralizing antibodies. RSV F stabilized in its pre-fusion conformation (DS-Cav1 F) induces high neutralizing antibody titers in naïve animals, but it remains unknown to what extent pre-fusion F can boost pre-existing neutralizing responses in RSV seropositive adults. We here assess DS-Cav1 F immunogenicity in seropositive cattle pre-exposed to bovine RSV, a virus closely related to hRSV. A single immunization with non-adjuvanted DS-Cav1 F strongly boosts RSV neutralizing responses, directed towards pre-fusion F-specific epitopes, whereas a post-fusion F is unable to do so. Vaccination with pre-fusion F thus represents a promising strategy for maternal immunization and for other RSV vaccine target populations such as older adults. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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