| Autor: |
Sun, Bingxia, Wang, Zhongwen |
| Předmět: |
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| Zdroj: |
Asian Journal of Organic Chemistry; Aug2019, Vol. 8 Issue 8, p1142-1150, 9p |
| Abstrakt: |
The nicotinic acetylcholine receptor (nAChR) is one of the targets for developing drugs for the treatment of central nervous system (CNS) disorders and for control of agricultural pests. Pyrido[3,4‐b] homotropane (PHT) was originally designed and synthesized by Kanne and co‐workers and showed strong affinity binding to nAChR. PHT has a novel aza‐[4.2.1]nonane skeleton. Owing to its excellent biological activities and novel chemical structure, synthetic and medicinal chemists have been attracted by this molecule. Some PHT analogues with bridged aza‐[n.2.1] skeletons were also designed and synthesized via different strategies. Herein, we summarize the syntheses of PHT and its analogues. Their biological activity study is also briefly discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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