| Autor: |
荒木 理沙, 藤江 敬子, 渡部 裕太, 唯根 菜々子, 鈐木 浩明, 礒田 博子, 橋本 幸一 |
| Předmět: |
|
| Zdroj: |
Pharmacometrics / Ōyō Yakuri (0300-8533); Jul2019, Vol. 96 Issue 5/6, p101-108, 8p |
| Abstrakt: |
Previously, we reported that the continuous intake of 330 m L of olive leaf tea (OLT) three times a day during mealtimes (320.8 m g of oleuropein daily) for 12 weeks markedly reduces blood lipid levels in individuals with pre-diabetes aged 40-70 years who are mildly obese or have normal-high body mass index. Recently, early prevention of lifestyle-related diseases has been regarded as important. Thus, we examined the preventive effects of O L T on serum lipid elevation in individuals with low risk of developing lifestyle-related diseases. A re-analysis of the aforementioned trial was performed, excluding the participants with abnormally high blood lipid levels: the triglyceride (TG) levels were less than 200 mg/dL, and low-density lipoprotein cholesterol (LDL-C) levels were less than 160 mg/dL. In this study, the geometric mean of T G levels at 12 weeks in the O L T group (n = 16) was 70.6 [95% confidence interval (CI): 61.9 to 85.9] mg/dL and lower than that in the control group (n = 16) (100.2 [95% CI: 87.2 to 125.8] mg/dL; p < 0.01). When limited to the participants with normal to borderline serum lipid levels, LDL-C levels at 12 weeks in the O L T group (n = 8) (114.6 [95%CI: 102.6 to 128.4] mg/dL) tended to be lower than those in the control group (n = 6) (129.0 [95% CI: 112.4 to 147.6] mg/dL; p = 0.059). Based on these results, it is expected that OLT could be effective in maintaining favorable blood lipid levels, even in individuals with relatively low blood lipid levels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
