| Autor: |
Pineda‐Peña, Elizabeth A., Meza‐Pérez, Dulce G., Chávez‐Piña, Aracely E., Velázquez‐Moyado, Josué A., Tavares‐Carvalho, José C., Navarrete Castro, Andrés |
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| Zdroj: |
Drug Development Research; Aug2019, Vol. 80 Issue 5, p585-594, 10p |
| Abstrakt: |
The aims of the study were to evaluate the pharmacodynamic interaction between 3α‐hydroxymasticadienonic acid and diligustilide (DLG), isolated from the plants Amphiptherygium adstringens and Ligusticum porteri, respectively, using the indomethacin‐induced gastric injury model, as well as their individual gastroprotective efficacy in this model. Male Wistar rats were orally administered with 3α‐hydroxymasticadienonic acid, DLG or the mixture of 3α‐hydroxymasticadienonic acid‐DLG (at a fixed‐ratio combination of 1:1, 1:3, and 3:1). Thirty minutes later, the gastric damage was induced by a single oral dose of indomethacin (30 mg/kg). Three hours later, the gastric injury (mm2) was determined. 3α‐hydroxymasticadienonic acid and DLG as individual compounds showed a gastroprotective effect against indomethacin‐induced gastric damage (p < .05). The effective dose (ED50) values for each compound were 6.96 ± 1.25 mg/kg for 3α‐hydroxymasticadienonic acid and 2.63 ± 0.37 mg/kg for DLG. The isobolographic analysis performed showed that the combination exhibited super‐additive interaction as the experimental ED50 values (Zexp) were lower than theoretical additive dose values (Zadd; p < .05). Our results identify the super‐additive (synergist) interaction between 3α‐hydroxymasticadienonic acid and DLG and the gastric safety of both compounds in the indomethacin—induced gastric injury model, suggesting their potential in the future as a strategy to decrease the gastric damage associated to the chronic use of nonsteroidal anti‐inflammatory drugs (NSAIDs). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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