Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery.

Autor: Xu, Weibing, Li, Guichen, Long, Haitao, Fu, Guorui, Pu, Lumei
Předmět:
Zdroj: New Journal of Chemistry; 8/21/2019, Vol. 43 Issue 31, p12215-12220, 6p
Abstrakt: The anticancer drug 6-MP was covalently bonded to the –OH group of poly(HPMA) via a glutathione-responsive carbonyl vinyl sulfide linker. In vitro simulation assay demonstrated that the poly(HPMA)–PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index