| Autor: |
Kotnova, A. P., Lyanova, B. M., Dukhanina, E. A., Portseva, T. N., Ilyin, Yu. V., Georgieva, S. G., Stepchenko, A. G., Pankratova, E. V. |
| Předmět: |
|
| Zdroj: |
Doklady Biochemistry & Biophysics; May2019, Vol. 486 Issue 1, p181-183, 3p |
| Abstrakt: |
Thapsigargin (SERCA ATPase inhibitor) inhibited the S100A4 metastatic marker expression in MDA-MB231 breast cancer cells. We found that S100A4 gene transcription is regulated by Ca2+ signaling pathways. We found that the synthesis of S100A4 mRNA and S100A4 protein in MDA-MB231 cells was effectively suppressed by thapsigargin at a concentration of 0.4–4 μM with retaining cell viability. We assume that the change in the gene transcription in response to disturbance of Ca2+ homeostasis is directly involved in the remodeling of Ca2+ signaling pathways. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
