Synthesis and antimicrobial activity of a phenanthroline-isoniazid hybrid ligand and its Ag+ and Mn2+ complexes.

Autor: Ahmed, Muhib, Rooney, Denise, McCann, Malachy, Devereux, Michael, Twamley, Brendan, Galdino, Anna Clara Milesi, Sangenito, Leandro Stefano, Souza, Lucieri Olegario Pereira, Lourenço, Maria Cristina, Gomes, Karen, dos Santos, André Luis Souza
Zdroj: BioMetals; Aug2019, Vol. 32 Issue 4, p671-682, 12p
Abstrakt: Hydrazide ligand, (Z)-N'-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag+ and Mn2+ complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1)2]NO3, [Ag(1)2]BF4 and [Mn(1)2](NO3)2. Polymeric {[Ag(1)(NO3)]}n has 1:1 stoichiometry and forms upon infusion of CH2Cl2 into a DMSO solution of [Ag(1)2]NO3. {[Ag(1)(NO3)]}n was structurally characterized using X-ray crystallography. Metal-free 1 and its 1:2 complexes exhibit very good, broad-spectrum antimicrobial activity and are not excessively toxic to mammalian cells (A549 lineage). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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