| Autor: |
Gündoğan, Cihan, Ergül, Nurhan, Çakır, Mehmet Semih, Aksoy, Tamer, Kılıçkesmez, Nuri Özgür, Çermik, Tevfik Fikret |
| Předmět: |
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| Zdroj: |
Nuclear Medicine Seminars; 2019 Supplement 1, Vol. 5, p12-13, 2p |
| Abstrakt: |
Aim: In this study, we investigated the diagnostic impact of staging Ga-68 prostate specific membrane antigen (PSMA) positron emission tomography/ computerized tomography (PET/CT) on patients with hepatocellular carcinoma (HCC). Method: Ten child pugh (CP)-A and 2 CP-B HCC patients [11 M, 1 F; mean age: 69±5.9 (range: 58-76) years] were enrolled in this prospective study. All patients underwent PSMA PET/CT scan and F-18 fluorodeoxyglucose (FDG) PET/CT scan which performed within 30 days of each other. Magnetic resonance imaging (MRI) was performed to all patients before included in the study. The maximum standardized uptake value (SUVmax) was measured for primary tumors, lymph nodes and distant metastases in PSMA PET/CT and FDG PET/CT. In addition to SUVmax, tumor-to-liver (T/L) and tumor-tobackground (T/B (gluteus medius muscle) taken into consideration. Liver tumors defined on PET/CT scans compared with MRI. Histopathology confirmed only in 4 patients. Results: In PET/CT imaging, increased PSMA uptake was observed in 9 patients, mild uptake was observed in two patinets and no uptake was observed in one patient [mean ± standard deviation (SD) SUVmax 19.8±12.4]. Four patients tumors were non-FDG avid, three patients showed mild FDG uptake and five patients showed increased FDG uptake (mean ± SD, SUVmax 9.3±5.6) (Table 1). PSMA uptake mean ratio for T/B was significantly higher in primary tumors compared with FDG (p=0.001). However, PSMA uptake mean ratio for T/L in primary tumors was higher than FDG, no significant difference was found (p=0.26). In our study group, 58 (98%) lesions were detected with PSMA PET/CT, while FDG PET/CT detected only 27 (46%) lesions. Seven (58%) patients had high-AFP-secreting tumors (>200 ng/mL) and 5 (42%) had low-AFP-secreting (<20 ng/mL) tumors. We did not find a relationship between AFP levels and PSMA or FDG uptake. Four patients had abdominal metastatic lymph nodes in PSMA PET/CT and one of them was non-FDG avid. Abdominal metastatic lymph nodes uptake in PSMA PET/CT was higher than FDG PET/CT in 3 of 4 patients. On the other hand, three patients had mediastinal lymph nodes metastases and these lesions FDG-PET/CT SUVmax levels are higher than PSMA PET/CT. Conclusion: In patients with HCC, PSMA PET/CT is superior to FDG PET/ CT as a molecular imaging modality, and we think PSMA PET/CT may be a potential new method in the diagnosis of primary tumors and metastatic lesions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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