| Autor: |
Gundoju, Narayanarao, Bokam, Ramesh, Yalavarthi, Nageswara Rao, Azad, Rajaram, Ponnapalli, Mangala Gowri |
| Předmět: |
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| Zdroj: |
Natural Product Research; Sep2019, Vol. 33 Issue 18, p2618-2622, 5p |
| Abstrakt: |
Chemical manipulation studies were conducted on betulinic acid (1), twenty-one new rationally designed analogues of 1 with modifications at C-28 were synthesized for their evaluation of inhibitory effects on α-glucosidase and LPS-stimulated nitric oxide production in mouse macrophage RAW 264.7 cells. Compound 2 (IC50 = 5.4 μM) exhibited an almost 1.4-fold increase in α-glucosidase inhibitory activity on yeast α-glucosidase while analogues 5 (IC50 16.4 μM) and 11 (IC50 16.6 μM) exhibited a 2-fold enhanced inhibitory activity on NO-production than betulinic acid. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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