| Autor: |
Hatem Al-Mugdadi, Suhad Faisal, Mohammed, Ahmed Salahuddin, Salman, Ahmed E., Alsayyid, Maha Mahamommed, Naser, Mustafa Mageed |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; May2019, Vol. 10 Issue 5, p1255-1261, 7p |
| Abstrakt: |
Both Her2 gene and Her2 protien are part of normal cell growth they seen in the breast cells of people without cancer, but sometime mistakes in a cell DNA and mutation cause the body to create many HER2 proteins. For diagnosis of HER-2/neu gene amplification, A total of 60 paraffin embedded breast tumors block from women with final histopathology diagnosis of invasive ductal breast carcinoma. All these samples were chosen as scored 2+ (equivocal) Her-2/neu by using Immunohistochemistry (IHC) technique. CISH as molecular method to detect Her-2/neu gene amplification was used. The high number and percentage (33/55%) of the breast cancer cases were found in pre-menopause Group < 50 years old. The highest number of the breast cancer cases grade ll was must common (42/70%). There were significant differences between age groups and between all histological grades. Stage ПIA was the highest one (25/ 41.7%) with significant differences between all stages. Using chromogenic in situ hybridization methods to detect HER2/neu gene the amplified cases were (36.6%).There were high significant differences between age, tumor grade and stage within amplified cases. CISH is hopeful to detect gene expression when the HER2/neu is score 2 (equivocal). It is valuable and considerable when correlated its results with the age, tumor grade and stage. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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