| Autor: |
Bertels, Zachariah, Pradhan, Amynah Amir Ali |
| Předmět: |
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| Zdroj: |
Headache: The Journal of Head & Face Pain; Jul2019 Supplement S2, Vol. 59, p50-65, 16p, 1 Chart |
| Abstrakt: |
Migraine is a complex disorder that is characterized by an assortment of neurological and systemic effects. While headache is the most prominent feature of migraine, a host of symptoms affecting many physiological functions are also observed before, during, and after an attack. Furthermore, migraineurs are heterogeneous and have a wide range of responses to migraine therapies. The recent approval of calcitonin gene‐related‐peptide based therapies has opened up the treatment of migraine and generated a renewed interest in migraine research and discovery. Ongoing advances in migraine research have identified a number of other promising therapeutic targets for this disorder. In this review, we highlight emergent treatments within the following biological systems: pituitary adenylate cyclase activating peptdie, 2 non‐mu opioid receptors that have low abuse liability – the delta and kappa opioid receptors, orexin, and nitric oxide‐based therapies. Multiple mechanisms have been identified in the induction and maintenance of migraine symptoms; and this divergent set of targets have highly distinct biological effects. Increasing the mechanistic diversity of the migraine tool box will lead to more treatment options and better patient care. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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