| Autor: |
Robinson, Brian D., Vlachostergios, Panagiotis J., Bhinder, Bhavneet, Liu, Weisi, Li, Kailyn, Moss, Tyler J., Bareja, Rohan, Park, Kyung, Tavassoli, Peyman, Cyrta, Joanna, Tagawa, Scott T., Nanus, David M., Beltran, Himisha, Molina, Ana M., Khani, Francesca, Miguel Mosquera, Juan, Xylinas, Evanguelos, Shariat, Shahrokh F., Scherr, Douglas S., Rubin, Mark A. |
| Zdroj: |
Nature Communications; 7/5/2019, Vol. 10 Issue 1, pN.PAG-N.PAG, 1p |
| Abstrakt: |
Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical phenotype. To define the biological features driving this phenotype, we performed an integrated analysis of whole-exome and RNA sequencing of UTUC. Here we report several key insights from our molecular dissection of this disease: 1) Most UTUCs are luminal-papillary; 2) UTUC has a T-cell depleted immune contexture; 3) High FGFR3 expression is enriched in UTUC and correlates with its T-cell depleted immune microenvironment; 4) Sporadic UTUC is characterized by a lower total mutational burden than urothelial carcinoma of the bladder. Our findings lay the foundation for a deeper understanding of UTUC biology and provide a rationale for the development of UTUC-specific treatment strategies. Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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