| Abstrakt: |
Transfusion therapy is accepted as a vital part of veterinary emergency and critical care medicine particularly in cases of acute hemolytic anemia in dogs. Whole blood surely benefits, but veterinarians face several procedural constraints for its instant procurement in emergency and prefer readily available substitutes to save the patient. This project aims to evaluate the efficacy of commonly available commercial synthetic colloids like Haemaccel® and Isoplasma® on splenectomised dogs compared to whole blood transfusion on their post-splenectomy anemic status, in terms of haemogram, reflecting two major body functions, viz., hematopoiesis and phagocytosis. This experiment was conducted on fifteen apparently healthy Nigerian indigenous adult male dogs with a mean live weight of 11.5±0.3 kg and aged between 2-3 years, out of which twelve dogs were splenectomised. Three dogs acted as blood donors. The splenectomised dogs were randomly divided into 4 groups with equal numbers in each group (n=3). Group A served as the control. Group B received whole blood. Group C received Haemaccel® and Group D received Isoplasma® during transfusion. Haematological parameters of different groups of dogs (A, B, C, D) were determined prior to the surgery (baseline) and then on 1st, 3rd, 7th, 10th, 14th, and 21st days after splenectomy. Haemogram of dogs was evaluated in respect of PCV, Hgb, RBCC, WBCC, DWBC, erythrocyte indices (MCV, MCH, MCHC) and reticulocytes. RBC count showed abrupt fall in Group A (control) dogs over the base line values after splenectomy. The RBC count in Group B (whole blood) dogs increased significantly (p=0.05) compared to Group C (Haemaccel®) dogs on psd- 1, 3, 7, 10 and 14 days, but did not differ (p=0.05) from Group D (Isoplasma®) dogs on psd- 7, 10 and 14 days. The RBC count of group D dogs was higher (p=0.05) than Group C dogs on psd- 1, 3, 7, 10 and 14 days. The WBC count showed abrupt rise in Group A (Control) dogs over the base line value on psd-1, declined sequentially up to psd-14 and became normal on psd- 21. The scenario was similar in respect of Group B (whole blood), Group C (Haemaccel®) and Group D (Isoplasma®) dogs. The WBC counts in Group B, Group C and Group D dogs were significantly (p=0.05) lower than Group A (control) dogs on psd- 7, 10, and 14 days, while the differences between Group B, Group C and Group D dogs were non-significant (p=0.05) on psd- 7, 10, and 14 days. The results indicated that transfusion of any of the synthetic colloids (Haemaccel® and Isoplasma®) was as good as whole blood to save the patient from acute hemolytic anemia. [ABSTRACT FROM AUTHOR] |
