| Autor: |
Lin, Edward, Gletsu, Nana, Fugate, Kim, McClusky, David, Gu, Li H., Juan-Li Zhu, Ramshaw, Bruce J., Papanicolaou, Dimitris A., Ziegler, Thomas R., Smith, C. Daniel |
| Předmět: |
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| Zdroj: |
Archives of Surgery; Jul2004, Vol. 139 Issue 7, p780-784, 5p |
| Abstrakt: |
Hypothesis Circulating ghrelin, produced primarily in the stomach, is a powerful orexigen. Ghrelin levels are elevated in states of hunger, but rapidly decline postprandially. Early alterations in ghrelin levels in morbidly obese patients undergoing weight reduction surgery may be attributed to gastric partitioning. Design and Patients Thirty-four patients underwent Roux-en-Y gastric bypass with a completely divided gastroplasty to create a 15-mL vertically oriented gastric pouch. Eight other patients underwent other gastric procedures that did not involve complete division of the stomach, including 4 vertical banded gastroplasties and 4 antireflux surgical procedures. Six additional patients undergoing antireflux surgery served as lean control subjects. Plasma samples were obtained before surgery and immediately after surgery. In a substudy, plasma was collected after Roux-en-Y limb formation and after dividing the stomach to identify any changes in plasma ghrelin levels. Setting Tertiary university medical center. Main Outcome Measures Ghrelin levels at different stages of surgical intervention. Results Mean ± SEM preoperative and postoperative ghrelin levels in the gastric bypass group were 355 ± 20 and 246 ± 13 pg/mL, respectively (P<.001). In the vertical banded gastroplasty group and in all patients undergoing antireflux surgery, ghrelin levels were not significantly changed. Conclusions Compared with morbidly obese humans, lean controls had significantly higher plasma ghrelin levels at baseline. A divided gastroplasty creating a small proximal gastric pouch results in significant early declines in circulating ghrelin levels that are not observed with other gastric procedures. This may explain, in part, the loss of hunger sensation and rapid weight loss observed following gastric bypass surgery. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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