| Autor: |
Liaskos, C., Rentouli, S., Simopoulou, T., Gkoutzourelas, A., Norman, G.L., Brotis, A., Alexiou, I., Katsiari, C., Bogdanos, D.P., Sakkas, L.I. |
| Předmět: |
|
| Zdroj: |
British Journal of Dermatology; Jul2019, Vol. 181 Issue 1, p138-146, 9p |
| Abstrakt: |
Summary: Background: Anti‐C1q autoantibodies (autoAbs) are associated with systemic lupus erythematosus (SLE), but their presence in other rheumatic diseases has not been adequately investigated. Objectives: We aimed to assess anti‐C1q autoAbs and circulating immune complexes (CICs) in systemic sclerosis (SSc). Methods: In total 124 patients with SSc were studied; 106 were female and the median age was 59·4 years (range 25–81·4). Overall 75 (60·5%) had limited cutaneous SSc and 49 (39·5%) had diffuse cutaneous SSc. Also included were 25 patients with Sjögren syndrome (SjS), 29 with rheumatoid arthritis (RA), 38 with SLE and 53 healthy controls. Enzyme‐linked immunosorbent assays with high‐ and low‐salt buffers were used to measure anti‐C1q antibodies and CICs. The former allows only anti‐C1q antibody binding to C1q and the latter also allows IgG Fc to bind to C1q. Results: Anti‐C1q antibodies were present in 20 of 124 (16·1%) patients with SSc: five had high levels (> 80 RU mL−1) and 10 (50%) had moderate levels (40–80 RU mL−1). Anti‐C1q antibodies were also present in one of 25 (4%) patients with SjS, one of 29 (3%) with RA (P < 0·05 for both) and three of 53 (6%) healthy controls (P < 0·01). Anti‐C1q antibodies were detected in 13 of 38 (34%) patients with SLEs. Anti‐C1q antibodies were more frequent in male than female patients with SSc (P = 0·005); this association remained after multivariate regression analysis. Anti‐C1q antibody level was the most important factor in predicting the presence of pulmonary fibrosis, and the second most important in predicting pulmonary arterial hypertension. Fourteen patients with SSc (11·3%) had CICs. Conclusions: Anti‐C1q autoAbs were frequently detected in patients with SSc, and their high levels predict the co‐occurrence of pulmonary fibrosis or pulmonary arterial hypertension. What's already known about this topic? In patients with systemic sclerosis (SSc) many autoantibodies are detected.Some autoantibodies in SSc are likely to be involved in the pathogenesis of the disease.Studies have reported complement activation in SSc.Studies investigating antibodies against C1q, which are frequently detected in systemic lupus erythematosus, have not been performed in SSc. What does this study add? Anti‐C1q antibodies are frequently detected in patients with SSc.Anti‐C1q antibody level is the most important risk factor for the presence of lung fibrosis. Plain language summary available online Respond to this article [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text