Competitive Induction and Enhancement of Indole and a Diketopiperazine in Marine Bacteria.

Autor: Trischman, Jacqueline A., Oeffner, Richard E., de Luna, Michelle G., Kazaoka, Martin
Předmět:
Zdroj: Marine Biotechnology; May/Jun2004, Vol. 6 Issue 3, p215-220, 6p
Abstrakt: Thirteen bacterial strains isolated from a sample of Ulva californica were cultured, extracted, and assayed for antibiotic activity. The target strains were 2 gram-positive isolates from the same algal sample. When cultured in monoculture, 2 of the 13 isolates produced extracts with antimicrobial activity. More significantly, one Bacillus isolate (UA-094) produced indole and cyclo(Phe-Pro) at active levels upon challenge with a different Bacillus target strain. These mildly antibiotic compounds were barely detectable in extracts without challenge. This technique of competitive induction and enhancement could be a valuable tool in the search for new antibiotics. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index