| Autor: |
Shetty, Amol C., Jacob, Christopher G., Huang, Fang, Li, Yao, Agrawal, Sonia, Saunders, David L., Lon, Chanthap, Fukuda, Mark M., Ringwald, Pascal, Ashley, Elizabeth A., Han, Kay Thwe, Hlaing, Tin Maung, Nyunt, Myaing M., Silva, Joana C., Stewart, Kathleen E., Plowe, Christopher V., O'Connor, Timothy D., Takala-Harrison, Shannon |
| Zdroj: |
Nature Communications; 6/17/2019, Vol. 10 Issue 1, pN.PAG-N.PAG, 1p |
| Abstrakt: |
Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites. Understanding genomic variation in Plasmodium falciparum parasites and inferring migration patterns can guide malaria elimination strategies. Using genome-wide data for 1722 parasites collected from 54 districts, the authors use identity-by-descent approaches to estimate regional parasite migration and spread of artemisinin drug resistance. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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