| Autor: |
Buxhofer-Ausch, Veronika, Ruckser, Reinhard, Kier, Peter, Habertheuer, Karl Heinz, Zelenka, Peter, Tatzreiter, Georg, Ausch, Christoph, Schmid, Isabel, Hruby, Walter, Reiner-Concin, Angelika, Sebesta, Christian, Ogris, Emil, Hinterberger-Fischer, Margareta, Hinterberger, Wolfgang |
| Předmět: |
|
| Zdroj: |
European Journal of Haematology; Aug2004, Vol. 73 Issue 2, p143-146, 4p |
| Abstrakt: |
Buxhofer-Ausch V, Ruckser R, Kier P, Habertheuer KH, Zelenka P, Tatzreiter G, Ausch C, Schmid I, Hruby W, Reiner-Concin A, Sebesta C, Ogris E, Hinterberger-Fischer M, Hinterberger W. A rare case of interstitial pneumonitis after tandem high-dose melphalan conditioning and autologous stem cell transplantation in multiple myeloma. Eur J Haematol 2004: 73: 143–146. © Blackwell Munksgaard 2004. A 57-yr-old woman with multiple myeloma received an autologous tandem transplant at a 4-month interval. She was conditioned twice with 225 mg/m2 melphalan. After the second transplant, interstitial pneumonitis (IP) ensued. The clinical course was life threatening and mechanical ventilation was required for 32 d. All attempts to identify an infectious agent failed. A presumptive diagnosis of idiopathic IP, possibly related to melphalan toxicity, was made. High-dose methylprednisolone administration led to rapid and durable improvement. Melphalan was employed for conditioning in the tandem setting with an interval of only 3–4 months between two courses or a dose elevation to 225 instead of 200 mg/m2, may have induced IP which responded favorably to methylprednisolone. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
