Administration of systemic antibiotics during non-surgical periodontal therapy—a consensus report.

Autor: Pretzl, B., Sälzer, S., Ehmke, B, Schlagenhauf, U., Dannewitz, B., Dommisch, H., Eickholz, P., Jockel-Schneider, Y.
Zdroj: Clinical Oral Investigations; Jul2019, Vol. 23 Issue 7, p3073-3085, 13p, 2 Diagrams, 4 Charts
Abstrakt: Aim: The aim of this meta-review was to evaluate whether there is a meaningful clinical benefit regarding the use of systemic adjunctive antibiotics in the treatment of patients with periodontitis. Additionally, a consensus regarding possible recommendations for future administration of antibiotics should be reached. Methods: A structured literature search was performed by two independent investigators focusing on systematic reviews (SR) covering adjunctive systemic antibiosis during non-surgical periodontal therapy. Additionally, recent randomized clinical trials (RCT, July 2015 to July 2017) were searched systematically to update the latest SR. Results were summarized and discussed in a plenary to reach a consensus. Results: Mostly, systematic reviews and RCTs showed a significant positive effect of adjunctive systematic antibiosis compared to controls. These positive effects gain clinical relevance in patients with severe periodontal disease aged 55 years and younger. Conclusion: Systemic antibiotics as an adjunct to non-surgical periodontal therapy should be sensibly administered and restrictively used. Only certain groups of periodontitis patients show a significant and clinically relevant benefit after intake of systemic antibiosis during periodontal therapy. Clinical relevance: Avoiding antibiotic resistance and possible side effects on the human microbiome should be a focus of dentists and physicians. Thus, a sensible administration of antibiotics is mandatory. This manuscript suggests guidelines for a reasonable use. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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