| Autor: |
Krasavin, E. A., Boreyko, A. V., Zadneprianetc, M. G., Ilyina, E. V., Kozhina, R. A., Kuzmina, E. A., Kulikova, E. A., Smirnova, E. V., Timoshenko, G. N., Tiounchik, S. I., Chausov, V. N. |
| Zdroj: |
Physics of Particles & Nuclei Letters; Mar2019, Vol. 16 Issue 2, p153-158, 6p |
| Abstrakt: |
The effect of the DNA synthesis inhibitors 1-β-D-arabinofuranosyl cytosine (AraC) and hydroxyurea (HU)—antitumor agents used in the clinic—on the formation of DNA double-strand breaks (DSBs) in human cells after irradiation with Bragg peak protons has been studied. It is shown that in the presence of AraC and HU the biological efficiency of proton irradiation, which is estimated based on γH2AX/53BP1 foci formation kinetics, increases sharply in the post-irradiation period. This is due to the formation of enzymatic DSBs from prolonged unrepaired single-strand DNA breaks. The proposed approach significantly increases the biological effectiveness of proton beams, thereby bringing the fields of the therapeutic use of proton and carbon ion accelerators much closer to each other. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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