Characteristics of pathogens and mortality predictors of older Chinese patients with nosocomial urinary tract infections.

Autor:	Hu, Wenxue, Xie, Shaoling, Yu, Feng, Hao, Wenke
Předmět:	MORTALITY risk factors ACINETOBACTER infections ANTIBIOTICS BLOODBORNE infections C-reactive protein CANDIDA albicans CONFIDENCE intervals CROSS infection LENGTH of stay in hospitals INTENSIVE care units MULTIVARIATE analysis PATHOGENIC microorganisms QUESTIONNAIRES URINARY tract infections LOGISTIC regression analysis RETROSPECTIVE studies DESCRIPTIVE statistics ODDS ratio
Zdroj:	Geriatrics & Gerontology International; Jun2019, Vol. 19 Issue 6, p541-546, 6p
Abstrakt:	Aim: The aim of the present study was to investigate predominant pathogens and predictors of 28‐day mortality of older Chinese patients with nosocomial urinary tract infections (NUTI). Methods: We retrospectively studied 1122 older patients (aged ≥60 years) with culture‐positive NUTI in Guangdong General Hospital, Guangzhou, China, from January 2009 to December 2014. The clinical features, microbial distributions and outcomes of these patients were recorded and compared between survival and death patients. Multivariate logistic regression was carried out to identify independent predictors of 28‐day mortality. Results: The present results showed the all‐cause mortality was 8.3%, and NUTI mortality was 1.43%. The proportions of Candida albicans (P = 0.004), Acinetobacter baumannii (P = 0.045) and Candida tropicalis (P < 0.001) in the death group were significantly higher than those in the survival group. Multivariate analysis showed two novel risk factors for mortality of older patients with NUTI, which were higher Charlson Comorbidity Index (odds ratio [OR] 1.205, 95% confidence interval (CI) 1.088–1.334] and lower level of serum prealbumin (OR 0.995, 95% CI 0.990–0.999). Furthermore, previous use of antibiotics (OR 1.984, 95% CI 1.106–3.559), inappropriate antimicrobial therapy (OR 1.883, 95% CI 1.144–3.098), intensive care unit stay (OR 4.082, 95% CI 2.469–6.749) and higher concentration of serum C‐reactive protein (OR 1.005, 95% CI 1.001–1.010) were independent prognostic factors for 28‐day mortality in older patients with NUTI. Conclusions: NUTI is associated with a high 28‐day in‐hospital mortality rate in older patients. We should evaluate the comorbidity, nutritional status, inflammatory markers, department staying and drug sensitivity test, and choose systematic therapy strategies for these older patients with NUTI. Geriatr Gerontol Int 2019; 19: 541–546. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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