| Autor: |
Shubina, Larisa Kimovna, Makarieva, Tatyana Nikolaevna, von Amsberg, Gunhild, Denisenko, Vladimir Anatolievich, Popov, Roman Sergeevich, Dyshlovoy, Sergey Anatolievich |
| Předmět: |
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| Zdroj: |
Natural Product Research; May2019, Vol. 33 Issue 10, p1415-1422, 8p |
| Abstrakt: |
A new pentacyclic guanidine alkaloid, monanchoxymycalin C (1) was isolated from a new collection of marine sponge Monanchora pulchra along with the known monanchoxymycalin A (2). The structure of 1 was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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