| Autor: |
Ragozzino, Giovanni, Mattera, Edi, Madrid, Elisa, Salornone, Patrizia, Fasano, Carmela, Gioia, Filornena, Acerra, Giusy, del Guercio, Raffaele, Federico, Pasquale |
| Předmět: |
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| Zdroj: |
Drugs in R&D; 2004, Vol. 5 Issue 4, p185-190, 6p |
| Abstrakt: |
Objective: To assess the efficacy of propionyl-carnitine (PC) in patients with type 2 diabetes and peripheral arterial disease (PAD). Patients and methods: This was an open pharmacodynamic study. Twenty-four obese patients with type 2 diabetes and PAD (stage IIb) were enrolled in the study. After an initial run-in period of 7 days on a low-calorie diet (1600 ± 150 kcal/day), patients received intravenous PC (600mg in 100mL saline solution Na/K 0.9%) twice daily for 10 days (T1). Results: Treatment with PC produced statistically significant increases in maximal walking distance (30%; p < 0.05) and initial claudication distance (15%; p < 0.05) in 15 and eight patients, respectively. In addition, a decrease in dosage of oral antihyperglycaemic agents was observed in 21 patients at T1. No PC-related adverse effects were reported. Conclusions: This study showed that acute intravenous administration of PC in patients with type 2 diabetes with PAD improved PAD-related symptoms as well as glycaemic control. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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