Dacomitinib in the Management of Advanced Non-Small-Cell Lung Cancer.
Autor: | Lau, Sally C. M., Batra, Ullas, Mok, Tony S. K., Loong, Herbert H. |
---|---|
Předmět: |
DIARRHEA
PARONYCHIA LUNG cancer prognosis EXANTHEMA STOMATITIS GEFITINIB ERLOTINIB DRUG toxicity LUNG cancer GENETIC mutation QUALITY of life SURVIVAL TUMOR classification DISEASE management PROTEIN-tyrosine kinase inhibitors TREATMENT effectiveness DISEASE progression DISEASE risk factors THERAPEUTICS |
Zdroj: | Drugs; Jun2019, Vol. 79 Issue 8, p823-831, 9p |
Abstrakt: | The use of targeted therapy in the management of epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer is an important milestone in the management of advanced lung cancer. There are several generations of EGFR tyrosine kinase inhibitors available for clinical use. Dacomitinib is a second-generation irreversible EGFR tyrosine kinase inhibitor with early-phase clinical studies showing efficacy in non-small-cell lung cancer. In the recently published ARCHER 1050 phase III study, dacomitinib given at 45 mg/day orally was superior to gefitinib, a first-generation reversible EGFR tyrosine kinase inhibitor, in improving both progression-free survival and overall survival when given as first-line therapy. There is no prospective evidence to support the use of dacomitinib as subsequent therapy in patients previously treated with chemotherapy or a first-generation EGFR tyrosine kinase inhibitor such as gefitinib and erlotinib. Dacomitinib has not demonstrated any benefit in unselected patients with non-small-cell lung cancer, and its use should be limited to those with known EGFR-sensitizing mutations. Dacomitinib is associated with increased toxicities of diarrhea, rash, stomatitis, and paronychia compared with first-generation EGFR inhibitors. Global quality of life was maintained when assessed in phase III studies. Overall, dacomitinib is an important first- line agent in EGFR-mutated non-small-cell lung cancer in otherwise fit patients whose toxicities can be well managed. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
Externí odkaz: |