| Autor: |
Stjernquist, M, Ekblad, E, Nordstedt, E, Radzuweit, C |
| Zdroj: |
Human Reproduction; Sep1991, Vol. 6 Issue 7, p1034-1038, 5p |
| Abstrakt: |
The human uterine artery was studied by immunocytochemistry and in vitro pharmacology. Nerve fibres containing immunoreactivity for neuropeptide Y (NPY) were encountered in the media, adventitia, smooth muscle layers and surrounding the vasa vasorum. Approximately 50% of the nerve fibres containing NPY also stored immunoreactivity for tyrosine hydroxylase (TH) and TH activity was found in no other fibres. Noradrenaline (NA) contracted the isolated uterine artery in a concentration dependent manner. The presence of increasing doses of NPY shifted the concentration-response curve for NA to the left. Consequently the pD2-values were increased indicating a potentiation of the adrenergic effects induced by NPY. The results demonstrate the existence of NPY in adrenergic nerve fibres surrounding the human uterine artery. A close co-operation between NPY and NA in the neuronal control of smooth muscle is suggested. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
