| Autor: |
Mackler, Bruce F., Faner, Richard M., Schur, Peter, Wright III, Thomas E., Levy, Barnet M. |
| Předmět: |
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| Zdroj: |
Journal of Periodontal Research; 1978, Vol. 13 Issue 5, p433-444, 12p |
| Abstrakt: |
Lymphocyte membrane-associated IgG subclass antibodies in human periodontal disease were studies to ascertain the relative presence of cytophilic IgG antibodies and the membrane Fe receptors which bind them. The experimental approach correlated the effect of incubating gingival in tissue culture medium to remove cytophilic antibodies with the changes in the number of Fc receptors detectable after washing. The evidence indicated that the majority of lymphocytes in mind gingivitis lesions lacked cytophilic IgG antibodies as well as Fc receptors. In severe gingivitis, the number of IgG subclass bearing lymphocytes increased to about half of the total lymphoid population, while the percentage of Fc receptor bearing cells remained quit low (12.3% ± 3.2, S.E.). The majority of IgG subclass bearing lymphocytes had membrane IgG which serve as receptors for antigen; such cells are classically defined as bone marrow (B) derived lymphocytes and serve as the progenitor for plasma cells. Gingival specimens for patients with periodontitis were found to contain the highest percentage of Fc receptor bearing lymphocytes (38.3% ± 12.6 S.E.) and cytophilic IgG antibodies. The finding indicate that the clinical stages of human periodontal disease are characterizes by different populations of infiltrating lymphocytes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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