| Autor: |
Samuel, Michelle, Thomasy, Sara M., Calderon, Allison S., Kass, Philip H., Collins, Keith, Murphy, Christopher J. |
| Předmět: |
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| Zdroj: |
Veterinary Ophthalmology; May2019, Vol. 22 Issue 3, p229-237, 9p |
| Abstrakt: |
Objective: To determine the effect of 5% sodium chloride ophthalmic ointment (5% NaCl) on thickness and morphology of the normal canine cornea using ultrasonic pachymetry (USP), in vivo confocal microscopy (IVCM), and Fourier‐domain optical coherence tomography (FD‐OCT). Methods: Five healthy laboratory Beagles received ophthalmic examinations including USP, IVCM, and FD‐OCT prior to and at fixed intervals following treatment. The right and left eyes were treated with 5% NaCl and artificial tears ophthalmic ointment (AT), respectively, every 2 hours for 4 treatments/d (days 2‐9), and then hourly for 7 treatments/d (day 10). Treatment groups were statistically compared using mixed‐effects linear regression. Results: Treatment with 5% NaCl resulted in a 12 μm decrease in corneal thickness from baseline (P < .001), while there was no significant difference in corneal thickness between values obtained at baseline and following treatment with AT (P = .82). Epithelial cell density significantly increased from baseline (530 ± 52 cells/mm2) to 577 ± 43 and 567 ± 15 cells/mm2 with 5% NaCl and AT, respectively (P = .003 and.005, respectively). However, keratocyte cell density in the anterior and posterior stroma and endothelial cell density did not significantly differ following treatment with 5% NaCl or AT ointment (P > .05). Conclusions: Short‐term topical treatment with 5% NaCl decreased corneal thickness in normal dogs with no observable changes in corneal morphology or signs of ocular toxicity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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