Upregulation of MicroRNA miR-9 Is Associated with Microcephaly and Zika Virus Infection in Mice.

Autor: Zhang, Haijun, Chang, Yafei, Zhang, Longbin, Kim, Seung-Nam, Otaegi, Gaizka, Zhang, Zhen, Nie, Yanzhen, Mubarak, Taufif, Li, Cui, Qin, Cheng-Feng, Xu, Zhiheng, Sun, Tao
Zdroj: Molecular Neurobiology; Jun2019, Vol. 56 Issue 6, p4072-4085, 14p
Abstrakt: Proper growth of the mammalian cerebral cortex, which is determined by expansion and survival of neural progenitors and mature neurons, is crucial for cognitive functions. Here, we show a role of the dosage of microRNA miR-9 in controlling brain size. Cortical-specific upregulation of miR-9 causes microcephalic defects in mice, due to apoptosis, reduced neural progenitor pool, and decreased neurogenesis. Glial cell-derived neurotrophic factor (GDNF) is a target of miR-9, and protects neural progenitors from miR-9-induced apoptosis. Furthermore, Zika virus (ZIKV) infection in embryonic mouse cortex causes reduced numbers in neural progenitors and newborn neurons, and results in upregulation of miR-9, downregulation of its target GDNF. Our studies indicate an association of altered levels of miR-9 and its target GDNF with microcephaly and ZIKV infection in mice. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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