| Autor: |
Nazarenko, M. S., Markov, A. V., Sleptcov, A. A., Koroleva, I. A., Sharysh, D. V., Zarubin, A. A., Valiahmetov, N. R., Goncharova, I. A., Muslimova, E. F., Kuznetsov, M. S., Kozlov, B. N., Afanasiev, S. A., Puzyrev, V. P. |
| Zdroj: |
Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Jan2019, Vol. 13 Issue 1, p74-80, 7p |
| Abstrakt: |
A comparative analysis of gene expression profiles of carotid atherosclerotic plaques and intact internal thoracic arteries of patients with advanced atherosclerosis was performed by using the Human-12 BeadChip Microarray (Illumina, USA). The most down-regulated genes in the carotid atherosclerotic plaques were APOD, FABP4, CIDEC, and FOSB, in contrast, up-regulated gene was SPP1 (|FC| > 64; pFDR < 0.05). The majority of differentially expressed genes were down-regulated in advanced atherosclerotic plaques. For example, genes involved in immune and inflammatory responses (arachidonic acid metabolism, cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, Jak-STAT signaling pathway, TNF signaling pathway) were down-regulated in advanced atherosclerotic plaques as compared with the healthy arteries. The most significant biological process of genes down-regulated in carotid atherosclerotic plaques (compared to intact internal thoracic arteries) was "cellular response to metal ions" (metallothioneins), and for upregulated genes was the organization of the extracellular matrix. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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