| Autor: |
Karlsson, Ingrid, Tingstedt, Jeanette Linnea, Şahin, Gülşen Özkaya, Hansen, Mikkel, Szojka, Zsofia, Buggert, Marcus, Biague, Antonio, Silva, Zacharias Da, Månsson, Fredrik, Esbjörnsson, Joakim, Norrgren, Hans, Medstrand, Patrik, Fomsgaard, Anders, Jansson, Marianne, Group, Sweden-Guinea-Bissau Cohort Research, Sahin, Gülsen Özkaya, Da Silva, Zacharias, Sweden-Guinea-Bissau Cohort Research Group |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 6/1/2019, Vol. 219 Issue 11, p1749-1754, 6p |
| Abstrakt: |
Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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