| Autor: |
Endo, Akira, Kitahara, Nobuaki, Oka, Hidehiko, Miguchi-Fukazawa, Yumi, Terahara, Akira |
| Předmět: |
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| Zdroj: |
European Journal of Biochemistry; 1/2/78, Vol. 82 Issue 1, p257-259, 3p |
| Abstrakt: |
A potent inhibitor of brain glutamate decarboxylase (L-glutamate 1-carboxy-lyase, EC 4.1.1.15) was isolated from cultures of a Streptomyces species, and its structure was found to be 4,5-dihydroxyisophthalic acid. The metabolite inhibited beef brain glutamate decarboxylase 50% at a concentration of 0.12 µg/ml (0.61 µM). The kinetic analysis indicated that 4,5-dihydroxyisophthalic acid was a competitive inhibitor having a Ki value of 0.18 µM. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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