Dicer regulates activation of the NLRP3 inflammasome.

Autor:	Ojcius, David M., Jafari, Ardavan, Yeruva, Laxmi, Schindler, Christian W., Abdul-Sater, Ali A.
Předmět:	NLRP3 protein INFLAMMASOMES BONE marrow AUTOIMMUNE diseases CHRONIC diseases SECRETION
Zdroj:	PLoS ONE; 4/23/2019, Vol. 14 Issue 4, p1-9, 9p
Abstrakt:	Inflammation plays a critical role in initiation of adaptive immunity, pathogen clearance and tissue repair. Interleukin (IL)-1β is a potent pro-inflammatory cytokine and therefore its production is tightly regulated: its secretion requires the assembly of a macromolecular protein complex, termed the inflammasome. Aberrant activation of the inflammasome has been linked to debilitating human diseases including chronic inflammatory and autoimmune diseases. Thus, there is a great interest in understanding how inflammasomes are regulated. Here we show that Dicer, an enzyme necessary for the production of mature micro-RNAs (miRNAs), is required for optimal activation of NLRP3 inflammasomes in bone marrow macrophages. Our data indicate that miRNAs may play an important role in promoting inflammasome activation. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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