Ethnopharmacological Inspections of Organic Extract of Oroxylum indicum in Rat Models: A Promising Natural Gift.

Autor:	Begum, Mst. Marium, Islam, Azharul, Begum, Rayhana, Uddin, Md. Sahab, Rahman, Md. Sohanur, Alam, Sumiya, Akter, Wahida, Das, Munny, Imon, A. H. M. Rahmatullah
Předmět:	DRUG therapy for hyperlipidemia ANALYSIS of variance ANIMAL experimentation ANTI-inflammatory agents ASPARTATE aminotransferase BARK BLOOD collection ETHANOL GLUCOSE tolerance tests HISTOLOGICAL techniques HYPERGLYCEMIA HYPOGLYCEMIC agents HYPOGLYCEMIC sulfonylureas INFLAMMATION LIVER MEDICINAL plants MICE SOLVENTS STATISTICS ULCERS PLANT extracts DATA analysis ALANINE aminotransferase SIMVASTATIN PHARMACODYNAMICS
Zdroj:	Evidence-based Complementary & Alternative Medicine (eCAM); 4/3/2019, p1-13, 13p, 1 Color Photograph, 11 Charts
Abstrakt:	The stem bark of Oroxylum indicum (O. indicum) was aimed at testing for anti-inflammatory, antiulcerative, antihyperglycemic, and antidyslipidemic activities. Liver enzyme concentration (SGPT, SGOT) had also been assessed. After being extracted in organic solvent, 3 distinct doses, 100, 200, and 400 mg/kg b.w. (p.o.), were used. For edema formation 0.1 ml carrageenan at a dose of 1% w/v was injected into paw of left hind. It showed a fall of edemas 37.50%, 48.34%, and 55.83% while used doses were 100, 200, and 400 mg/kg b.w. (p.o.) individually. The EtOH extract of O. indicum (50%) and its fractions PET, CLF, EtOAc, and nBUT were studied against ethanol-induced gastric mucosal damage. Only PET and n-BuOH exhibited the highest percentage of protection and were 96% and 99%, respectively, persuaded by ethanol. In OGTT glibenclamide revealed reduction of glucose level to 7.55 ± 0.22 mmol/L from 10.57 ± 0.32 mmol/L after 30 minutes. Antihyperglycemic activities were assessed for 8- and 12-week duration in diabetic rats. Glibenclamide reduced glucose level from 33.50±0.31 to 7.90±0.19 mmol/L in 12 weeks. In 12 and 8 weeks, combination therapy lowered blood glucose level to a normal extent by 79% and 61% individually. In antidyslipidemic activities after 12-week treatment, it revealed simvastatin; MEOI (400 mg/kg b.w.) and combination of both reduced TC level by 44%, 28%, and 48% consequently followed by TG and LDL. In 8-week treatment, HDL levels were increased by 34%, 13%, and 36%, and in 12 weeks increased by 36%, 8%, and 38% consequently. Liver enzyme concentration after 12 weeks of treatment with glibenclamide, 400 mg/kg b.w. (p.o.) of MEOI and combination of both, exhibited the fact that concentration of SGPT showed downturn by 43.23%, 8.01%, and 54.86% and SGOT by 42.40%, 5.31%, and 44.85%. This study remarked that O. indicum has anti-inflammatory, antiulcer, antidiabetic, and antidyslipidemic potentials but has no ameliorative effect on liver enzyme. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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