| Autor: |
Casamayor-Palleja, Montserrat, Feuillard, Jean, Ball, Jennifer, Drew, Marion, MacLennan, Ian C. M. |
| Zdroj: |
International Immunology; May1996, Vol. 8 Issue 5, p737-744, 8p |
| Abstrakt: |
B cells, after mutating their Ig V-region genes in germinal centres (GC), undergo apoptosis, unless they receive antigen-dependent selection signals. The signals appear to be delivered by GC T cells, require CD40 ligand expression and may induce differentiation to memory cells. Cultured GC B cells are prevented from entering apoptosis by ligating their surface CD40, but the resulting phenotype is not that associated with B cells found in vivo. Conversely, GC B cells rapidly adopt a memory B cell phenotype on culture with autologous memory CD4+ T cells that have been induced to express CD40 ligand transiently. This effect is prevented by blocking CD4+ ligand. Naive CD4+ T cells, induced to express CD40 ligand, do not prevent GC B cells undergoing apoptosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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