| Autor: |
Ou, Qiong, Chen, Baixin, Loffler, Kelly A., Luo, Yuanming, Zhang, Xilong, Chen, Rui, Wang, Qian, Drager, Luciano F., Lorenzi-Filho, Geraldo, Hlavac, Michael, McArdle, Nigel, Mukherjee, Sutapa, Mediano, Olga, Barbe, Ferran, Anderson, Craig S., McEvoy, R. Doug, Woodman, Richard J., SAVE investigators |
| Předmět: |
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| Zdroj: |
CHEST; Apr2019, Vol. 155 Issue 4, p720-729, 10p |
| Abstrakt: |
Background: Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established.Methods: This study was a post hoc analysis of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a multicenter, randomized trial of CPAP plus standard care vs standard care alone in adults with a history of cardiac or cerebrovascular events and moderate to severe OSA. Participants with weight, BMI, and neck and waist circumferences measured at baseline and during follow-up were included. Linear mixed models were used to examine sex-specific temporal differences, and a sensitivity analysis compared high CPAP adherers (≥ 4 h per night) with propensity-matched control participants.Results: A total of 2,483 adults (1,248 in the CPAP group and 1,235 in the control group) were included (mean 6.1 ± 1.5 measures of weight available). After a mean follow-up of 3.78 years, there was no difference in weight change between the CPAP and control groups, for male subjects (mean [95% CI] between-group difference, 0.07 kg [-0.40 to 0.54]; P = .773) or female subjects (mean [95% CI] between-group difference, -0.14 kg [-0.37 to 0.09]; P = .233). Similarly, there were no significant differences in BMI or other anthropometric measures. Although male participants who used CPAP ≥ 4 h per night gained slightly more weight than matched male control subjects without CPAP (mean difference, 0.38 kg [95% CI, 0.04 to 0.73]; P = .031), there were no between-group differences in other anthropometric variables, nor were there any differences between female high CPAP adherers and matched control subjects.Conclusions: Long-term CPAP use in patients with comorbid OSA and cardiovascular disease does not result in clinically significant weight change.Trial Registry: ClinicalTrials.gov; No.: NCT00738179; URL: www.clinicaltrials.gov. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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