| Autor: |
Bryan, Christopher F., Cherikh, Wida S., Cheng, Yulin, Aeder, Mark I., Muruve, Nicolas A., Nelson, Paul W., Shield III, Charles F., Warady, Bradley A., Winklhofer, Franz T. |
| Předmět: |
|
| Zdroj: |
Clinical Transplantation; Oct2004 Supplement 12, Vol. 18, p55-60, 6p, 5 Charts, 1 Graph |
| Abstrakt: |
Bryan CF, Cherikh WS, Cheng Y, Aeder MI, Muruve NA, Nelson PW, Shield III CF, Warady BA, Winklhofer FT. ABO blood group influences a candidate's likelihood of receiving an HLA zero antigen mismatch kidney. Clin Transplant 2004: 18 (Suppl. 12): 55–60. © Blackwell Munksgaard, 2004 National sharing of HLA zero-mismatched kidneys has improved long-term graft survival. The distribution of those HLA-matched kidneys by ABO blood group, however, has not been examined. Utilizing the UNOS/OPTN (United Network for Organ Sharing/Organ Procurement Transplantation Network) database, we analysed 112 971 kidney waiting list registrations added during 6/3/95–31/12/00, and 8162 HLA zero-mismatched (0 mm) primary kidney transplants in the USA during 1/1/88–31/3/02. We also analyzed A isoagglutinin titer histories for 87 blood group B end stage renal disease (ESRD) patients for whom at least 1 yr of testing was done. Blood group A patients received 40.1% of the HLA-0 mm kidneys while having a 26.5% representation on the national waiting list. Blood group B patients comprised 17.4% of the waiting list, but received only 10.4% of the HLA-0 mm kidneys. Most (89.6%) blood group B patients awaiting kidney transplantation have low levels of A isoagglutinins, making them eligible to receive a blood group A2 kidney transplant. The national HLA-0 mm kidney allocation sharing system's imbalance by ABO blood group could be partially resolved in the future by allocating HLA-0 mm blood group A2 kidneys to B patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
