| Autor: |
Al-Shameri, Ammar, Borlinghaus, Niels, Weinmann, Leonie, Scheller, Philipp N., Nestl, Bettina M., Lauterbach, Lars |
| Předmět: |
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| Zdroj: |
Green Chemistry; 3/21/2019, Vol. 21 Issue 6, p1396-1400, 5p |
| Abstrakt: |
Herein, we report an enzymatic cascade involving an oxidase, an imine reductase and a hydrogenase for the H2-driven synthesis of N-heterocycles. Variants of putrescine oxidase from Rhodococcus erythropolis with improved activity were identified. Substituted pyrrolidines and piperidines were obtained with up to 97% product formation in a one-pot reaction directly from the corresponding diamine substrates. The formation of up to 93% ee gave insights into the specificity and selectivity of the putrescine oxidase. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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