Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC).
| Autor: | Rosenhall, Ulf, Skoog, Björn, Muhr, Per |
|---|---|
| Předmět: |
CYSTEINE
ACCIDENTS ANTIOXIDANTS AUDIOMETRY CONFIDENCE intervals NOISE-induced deafness HEARING disorders HEARING levels MILITARY research SCIENTIFIC observation RESEARCH funding MILITARY personnel SOUND TINNITUS WEAPONS RELATIVE medical risk DISEASE incidence DISEASE prevalence RETROSPECTIVE studies THERAPEUTICS |
| Zdroj: | International Journal of Audiology; Mar2019, Vol. 58 Issue 3, p151-157, 7p, 5 Charts, 2 Graphs |
| Abstrakt: | Objective: To study if the antioxidant (AO) N-Acetyl-L-cysteine (NAC) reduces the risk of hearing loss after acoustic accidents in humans. Design: A retrospective, observational study. Study sample: Personnel of the Swedish Armed Forces (SAF) exposed to military acoustic accidents during a 5 year period. Included in the study were 221 cases (mean age: 22.9 years). Most of the exposures, 84%, were weapon related. NAC (400 mg) was given directly after the accident in 146 cases; 75 had not received NAC. Results: The prevalence of hearing thresholds ≥25 dB HL, and the incidence of threshold shifts ≥10 dB, was lower in the NAC group than in the non-NAC group directly after the noise exposure. The deterioration was temporary and not discernable a long time after the accident. The difference was most pronounced in the right ear. The risk reduction to get a temporary hearing loss (TTS), affecting one or both ears was 39% (significant) in the NAC group. Conclusions: The study has demonstrated a significant reduction of the incidence of TTS by the use of NAC. Since cases of both permanent hearing loss (PTS) and noise-induced tinnitus are recruited from cases with TTS, the demonstrated risk reduction indicates a positive effect of NAC. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
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