| Autor: |
Hassan, Rocío, Otazú, Ivone B., Ornellas, Maria Helena, Pires, Virginia, Carriço, Maria Kadma, Seuaacute;nez, Héctor N., Tabak, Daniel G., Zalcberg, Ilana R. |
| Předmět: |
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| Zdroj: |
Leukemia & Lymphoma; Sep2004, Vol. 45 Issue 9, p1925-1929, 5p |
| Abstrakt: |
Philadelphia positive (Ph+) acute myeloid leukemia (AML) is a rare and heterogeneous condition, mainly reported in adults, associated to poor prognosis and unfavorable response to therapy. Here we report clinical and laboratory findings in an 8-year-old patient diagnosed with Ph+ acute leukemia with myeloid (FAB M4) morphology. The patient consistently expressed variable levels of m-bcr, e1a2 transcripts during a 42-month follow-up after two different stem cell transplantation protocols. An immunophenotypic switch was documented, from a mixed, myeloid-lymphoid lineage to a full lymphoid phenotype following stem cell transplants, in association with an immature B-cell gene rearrangement profile and clonal instability during clinical progression. This report indicates a stem cell origin as previously suggested for Ph+ AML. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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