Clinical Relevance of C4d Deposition in Pediatric Immunoglobulin A Nephropathy.

Autor: Baek, Hee Sun, Hoon Han, Man, Jin Kim, Yong, Hyun Cho, Min
Předmět:
Zdroj: Fetal & Pediatric Pathology; Oct2018, Vol. 37 Issue 5, p326-336, 11p
Abstrakt: Introduction: Few studies have reported the association between the complement cascade and pediatric immunoglobulin A nephropathy (IgAN). This study aimed to investigate the association between C4d staining positivity and the clinical/histopathological characteristics of pediatric patients with IgAN. Methods: Children diagnosed with IgAN through renal biopsy were retrospectively reviewed. Renal biopsy specimens were stained using C4d immunohistochemistry. Results: Among the 56 patients, 31 (55.4%) showed positive mesangial or peripheral capillary C4d staining in glomeruli. Urine protein-to-creatinine ratio was significantly higher in C4d-positive patients (p = 0.001). The severity of mesangial proliferation according to the Haas and Oxford classification was positively associated with positive C4d staining (p < 0.001). Conclusion: Positive C4d staining was found to be significantly associated with the clinical/histopathological severity of IgAN. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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