| Autor: |
Piperno, Anna, Zagami, Roberto, Cordaro, Annalaura, Pennisi, Rosamaria, Musarra-Pizzo, Maria, Scala, Angela, Sciortino, Maria Teresa, Mazzaglia, Antonino |
| Zdroj: |
Journal of Inclusion Phenomena & Macrocyclic Chemistry; Feb2019, Vol. 93 Issue 1/2, p33-40, 8p |
| Abstrakt: |
In the framework of our studies dealing with the development of new platforms for the delivery of antiviral agents, we exploited the covalent approach based on click chemistry to link β-cyclodextrin (CD) on hyaluronic acid backbone (HA). The physico-chemical properties in terms of size, surface charge, interaction with acyclovir (Acy), selected as a model antiviral drug, have been investigated. The release profile and the biological properties (cytotoxicity and inhibition of viral plaque formation) of HA-CD/Acy complex pointed out a good antiviral activity together with a delayed-release of Acy from HA-CD/Acy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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